Calico Life Sciences LLC, a pioneering research and development company founded by Alphabet, is dedicated to advancing our understanding of the biology of aging to enhance human healthspan. We are currently seeking a Principal Investigator in Cardiovascular Research to spearhead our laboratory investigations and drug development initiatives targeting cardiovascular diseases associated with aging. This role requires a seasoned professional with a strong background in cardiovascular biology and drug discovery. The successful candidate will design and implement innovative research strategies aimed at identifying and validating novel drug targets. This position offers an opportunity to contribute to impactful research in a collaborative environment, leveraging Calico’s cutting-edge technologies and partnerships. Join us in our mission to develop transformative interventions that promote longer, healthier lives through scientific discovery and innovation.
| At-a-Glance | |
|---|---|
| Location | South San Francisco, California |
| Salary | $220,000 – $241,000 |
| Closing Date | 7 Oct 2025 |
| Discipline | Life Science |
| Job Type | Principal Investigator |
| Duration | Permanent |
| Hours | Full time |
| Sector | Industry |
| Qualification | PhD |
Calico Life Sciences LLC, an innovative research and development company founded by Alphabet, is dedicated to advancing our understanding of the biology of aging and its implications for human health. The role of Principal Investigator, Cardiovascular Research, based in South San Francisco, California, is pivotal in driving the company’s mission to develop interventions that promote longer and healthier lives through targeted research in cardiovascular diseases associated with aging.
In this key position, the Principal Investigator will lead a dedicated team of scientists focused on identifying and validating novel drug targets that address age-related cardiovascular conditions. This involves designing and executing comprehensive research strategies that leverage both in vitro and in vivo models to investigate the mechanisms underlying cardiovascular diseases. The ideal candidate will possess a robust background in cardiovascular biology, aging research, and drug discovery, complemented by significant experience in target identification and validation.
The Principal Investigator will oversee the implementation of innovative research approaches while collaborating with cross-functional teams, including medicinal chemistry and translational research, to advance the company’s drug discovery programs. Staying informed about the latest scientific advancements in cardiovascular disease and aging biology will be essential for guiding the team’s efforts and ensuring that Calico remains at the forefront of research in this critical area.
In addition to leading laboratory investigations, the Principal Investigator will represent Calico at scientific conferences and meetings, fostering collaborations and disseminating findings to the broader scientific community. This role not only emphasizes leadership and mentorship but also offers a unique opportunity to contribute directly to the development of therapeutics aimed at improving cardiovascular healthspan, aligning with Calico’s commitment to curiosity-driven discovery and impactful medical breakthroughs.
Responsibilities
- Lead and design innovative cardiovascular research projects to advance scientific knowledge and clinical applications.
- Secure funding through grant proposals and manage budgets for ongoing research initiatives.
- Supervise and mentor research staff, including graduate students and postdoctoral fellows.
- Collaborate with interdisciplinary teams to enhance research outcomes and share findings.
- Ensure compliance with ethical standards and regulatory requirements in all research activities.
- Publish research findings in peer-reviewed journals and present at scientific conferences.
Qualifications
- Ph.D. in cardiovascular biology, medicine, or related field with extensive research experience.
- Proven track record of leading independent research projects and securing funding.
- Strong publication record in high-impact peer-reviewed journals.
- Expertise in experimental design, statistical analysis, and data interpretation.
- Excellent communication skills for collaboration and presenting research findings.
- Ability to mentor and guide junior researchers and students effectively.
Benefits
- Leads groundbreaking studies that advance cardiovascular health and treatment options.
- Collaborates with multidisciplinary teams, enhancing professional network and research impact.
- Secures funding opportunities, boosting institutional resources and research capabilities.
- Mentors emerging scientists, fostering the next generation of cardiovascular researchers.
